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The synthesis of novel 2,4,6-trisubstituted 1,3,5-triazines: a search for potential MurF enzyme inhibitorsSosič, Izidor ...A series of new 2,4,6-trisubstituted 1,3,5-triazines, possessing a variety of substituents (-OH, -SH, -OMe, -Cl, -HNR, -SR and amino acid moieties), were synthesized and evaluated for the inhibition ... of the bacterial peptidoglycan biosynthesis enzyme MurF. Ethoxycarbonyl isothiocyanate successfully reacted with a variety of amidines, enabling an approach to 6-substituted-4-thioxo-1,3,5-triazin-2-ones. Also, a representative set of 2-thio-, 2-amino-, and 2-oxo-substituted 1,3,5-triazines was synthesized by the SNAr reaction, employing 2,4,6-trichloro-1,3,5-triazine and 2-chloro-4,6-dimethoxy- 1,3,5-triazine as the starting materials. One compounddisplayed notable inhibitory activity against MurF from Escherichia coli.Source: Heterocycles. - ISSN 0385-5414 (Vol. 81, no. 1, 2010, str. 91-115)Type of material - article, component partPublish date - 2009Language - englishCOBISS.SI-ID - 2697329
Author
Sosič, Izidor |
Štefane, Bogdan |
Kovač, Andreja, farmacevtka, 1979- |
Turk, Samo |
Blanot, Didier |
Gobec, Stanislav, 1970-
Topics
encimski inhibitorji |
MurF |
1,3,5-triazini |
sinteza
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sosič, Izidor | 30816 |
Štefane, Bogdan | 18423 |
Kovač, Andreja, farmacevtka, 1979- | 27782 |
Turk, Samo | 29773 |
Blanot, Didier | |
Gobec, Stanislav, 1970- | 15284 |
Source: Personal bibliographies
and: SICRIS
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