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Obesity measures and dietary parameters as predictors of gut microbiota phyla in healthy individuals [Elektronski vir]Bezek, Katja ...: The dynamics and diversity of human gut microbiota that can remarkably influence the wellbeing and health of the host are constantly changing through the host%s lifetime in response to various ... factors. The aim of the present study was to determine a set of parameters that could have a major impact on classifying subjects into a single cluster regarding gut bacteria composition. Therefore, a set of demographical, environmental, and clinical data of healthy adults aged 25%50 years (117 female and 83 men) was collected. Fecal microbiota composition was characterized using Illumina MiSeq 16S rRNA gene amplicon sequencing. Hierarchical clustering was performed to analyze the microbiota data set, and a supervised machine learning model (SVM; Support Vector Machines) was applied for classification. Seventy variables from collected data were included in machine learning analysis. The agglomerative clustering algorithm suggested the presence of four distinct community types of most abundant bacterial phyla. Each cluster harbored a statistically significant different proportion of bacterial phyla. Regarding prediction, the most important features classifying subjects into clusters were measures of obesity (waist to hip ratio, BMI, and visceral fat index), total body water, blood pressure, energy intake, total fat, olive oil intake, total fiber intake, and water intake. In conclusion, the SVM model was shown as a valuable tool to classify healthy individuals based on their gut microbiota composition.Source: Nutrients [Elektronski vir]. - ISSN 2072-6643 (Vol. 12, iss. 9, 2020, str. 1-18)Type of material - e-article ; adult, seriousPublish date - 2020Language - englishCOBISS.SI-ID - 27489283
Author
Bezek, Katja |
Petelin, Ana, 1978- |
Pražnikar, Jure |
Nova, Esther |
Redondo, Noemi |
Ascensión, Marcos |
Jenko Pražnikar, Zala
Topics
črevesna mikrobna združba |
prehrana |
debelost |
življenjski slog |
klastriranje |
gut microbiota |
nutrition |
obesity |
lifestyle parameters |
clustering
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Bezek, Katja | 35374 |
Petelin, Ana, 1978- | 24764 |
Pražnikar, Jure | 24270 |
Nova, Esther | |
Redondo, Noemi | |
Ascensión, Marcos | |
Jenko Pražnikar, Zala | 24263 |
Source: Personal bibliographies
and: SICRIS
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