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Comparable effectiveness and immunomodulatory actions of oxaliplatin and cisplatin in electrochemotherapy of murine melanomaUršič Valentinuzzi, Katja, 1990- ...Interest in platinum-based chemotherapeutics such as oxaliplatin (OXA) and cisplatin (CDDP) has been reinvigorated by their newly described impacts on tumor-specific immune responses. In addition to ... CDDP, OXA is frequently used to treat cancers. Based on the characteristics of OXA, which are similar to those of CDDP, and the presumably more pronounced immunomodulatory effect of OXA, OXA is a candidate for electrochemotherapy (ECT). We compared the effectiveness of intratumoral ECT with OXA to that of ECT with CDDP in murine B16F10 melanoma to determine the equieffective dose. Special attention was given to the elicitation of immunogenic cell death and local immune response. Based on the in vitro and in vivo results pertaining to effectiveness and drug uptake in cells and tumors, ECT with OXA is as effective as ECT with CDDP when the OXA dose is increased 1.6-fold. Exposure of melanoma cells to ECT induces immunogenic cell death when either OXA or CDDP is used, which correlates with a comparable increase in lymphocyte infiltration into tumors after ECT with either OXA or CDDP. Based on these results, OXA is a valid platinum-based drug for use with ECT, and the effectiveness of ECT with OXA is comparable to that of the well-established ECT with CDDP. Furthermore, both drugs display equal and specific immune responses following ECT.Source: Bioelectrochemistry. - ISSN 1567-5394 (Vol. 119, Feb. 2018, str. 161-171)Type of material - article, component partPublish date - 2018Language - englishCOBISS.SI-ID - 2756731
Author
Uršič Valentinuzzi, Katja, 1990- |
Kos, Špela, farmacija |
Kamenšek, Urška |
Čemažar, Maja |
Ščančar, Janez |
Buček, Simon, 1983- |
Kranjc Brezar, Simona |
Lisec, Barbara, 1991- |
Serša, Gregor
Topics
elektrokemoterapija |
cisplatin |
oxaliplatin |
melanom |
imunogena celična smrt |
imunski odgovor |
electrochemotherapy |
melanoma |
immunogenic cell death |
immune response |
oxaliplatin |
cisplatin
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Uršič Valentinuzzi, Katja, 1990- | 38223 |
Kos, Špela, farmacija | 36366 |
Kamenšek, Urška | 28387 |
Čemažar, Maja | 14575 |
Ščančar, Janez | 18359 |
Buček, Simon, 1983- | 39955 |
Kranjc Brezar, Simona | 19058 |
Lisec, Barbara, 1991- | 39122 |
Serša, Gregor | 08800 |
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