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C-type lectin DC-SIGN; an adhesion, signalling and antigen-uptake molecule that guides dendritic cells in immunityŠvajger, Urban ...The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells ... (APCs), the dendritic cells (DCs). In recent years, DC-SIGN has gained an exponential increase in attention because of its involvement in multiple aspects of immune function. Besides being an adhesion molecule, particularly in binding ICAM-2 and ICAM-3,it is also crucial in recognizing several endogenous and exogenous antigens. Additionally, the intracellular domain of DC-SIGN includes molecular motifs, which enable the activation of signal transduction pathways involving Raf-1 and subsequent modulation of DC-maturation status, through direct modification of nuclear factor Nf-?B in DCs. Upon DC-SIGN engagement bymannose- or fucose-containing oligosaccharides, the latter leads to a tailored Toll-like receptor signalling, resulting in an altered DC-cytokine profile and skewing of Th1/Th2 responses. In this article, we will discuss recent advances on a broad perspective concerning DC-SIGN structure, signalling and immune function.Source: Cellular signalling. - ISSN 0898-6568 (Vol. 22, iss. 10, 2010, str. 1397-1405)Type of material - article, component partPublish date - 2010Language - englishCOBISS.SI-ID - 2770545
Link(s):
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T2M-4YRXD4F-3&_user=4776866&_coverDate=10%2F31%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=ed5d13d6f812d844c82de952f66f809f&searchtype=a
DOI
Author
Švajger, Urban |
Anderluh, Marko |
Jeras, Matjaž |
Obermajer, Nataša
Topics
dendritične celice |
imunsko modeliranje |
patogenski receptorji |
adhezija |
migracije
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Švajger, Urban | 26198 |
Anderluh, Marko | 21456 |
Jeras, Matjaž | 01302 |
Obermajer, Nataša | 25494 |
Source: Personal bibliographies
and: SICRIS
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