-
Simulacija pljuč, alveolne ventilacije ter njenega uravnavanja z negativno povratno zvezo : doktorsko deloDolenšek, JanezIn the medical research and in teaching various models are used. They very often use digital (mathematical) modelling (simulation) of various physiological processes. However, mathematical modelling ... is demanding and therefore not easily accessible. Therefore in this investigation another approach is usedČ analogue simulation. By using the Electronics Workbench software an electronic equivalent circuit is designed, simulating the lung andits ventilation. The circuit is upgraded by including a negative feedback to control alveolar ventilation. Simulations were performed under the conditions in which the negative feedback loop was either open or closed. In the first experimental condition, when negative feedback was not operative, only the immediate consequences of the disturbance could be observed. In the second experimental condition, when negative feedback was operative, complex homeostatic phenomena could be observed. The latter - in principle - minimizesthe consequences of the initial disturbance. Under the conditions in which the negative feedback loop was either open or closed, three different types of disturbance were studiedČ i) increased production of CO2, ii) temporary apnea and iii) increased aiarway resistance (bronchoconstriction). The heterogeneous lung model was used to simulate bronchoconstriction in the entire lung. The heterogeneous lung model was used to simulate bronchoconstriction in only one section, comprising a half of the lung. Increased production of CO2 resulted in an increase of tidal volume and in increased arterial pCO2. The latter was highly dependent on the response of the negative feedback. Temporary apnea resulted in a temporary increase in pCO2. When, in the feedback loop, the delay in signal transfer was relatively large, temporary apnea induced the periodic, i.e. Cheyne-Stokes breathing. Bronchoconstriction which affected the whole lung resulted in a decrease in the tidal volume. (Abstract truncated at 2000 characters).Type of material - dissertationPublication and manufacture - Ljubljana : [J. Dolenšek], 2005Language - slovenianCOBISS.SI-ID - 2805524
Author
Dolenšek, Janez
Other authors
Kordaš, Marjan |
Meznarič, Marija
Topics
Respiration |
Physiology |
Gases |
Blood |
Feedback, biochemical |
Physiology |
Down |
Regulation |
Models, biological |
Computer simulation |
Methods |
Dihanje |
Fiziologija |
Plini |
Kri |
Povratna zveza, biokemična |
Fiziologija |
Negativna regulacija |
Biološki modeli |
Računalniška simulacija |
Metode |
fiziologija
Library/institution |
City | Acronym | For loan | Other holdings |
---|---|---|---|---|
MF, Central Medical Library, Ljubljana | Ljubljana | CMK |
outside loan 2 cop.
|
|
National and University Library, Ljubljana | Ljubljana | NUK |
reading room 1 cop.
|
|
University of Maribor Library | Maribor | UKM |
reading room 1 cop.
|
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Dolenšek, Janez | 20388 |
Kordaš, Marjan | 01187 |
Meznarič, Marija | 04905 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.