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  • The endothelial plasma membrane transporter bilitranslocate mediates rat aortic vasodilation induced by anthocyanins
    Žiberna, Lovro ...
    Background and aims: Anthocyanins, a sub-class of flavonoids, induce endothelium dependent vasorelaxation, by activating endothelial nitric oxide synthase and consequently increasing production of ... the vasorelaxant agent nitric oxide. It is not yet clear if anthocyanin-induced vasorelaxation startswith their interaction with plasma membrane receptors in the extracellular compartment, or with their membrane transport toward intracellular molecular targets. We therefore investigated the possible role of bilitranslocase (TC 2.A.65.1.1), an endothelial plasma membrane carrier that transports flavonoids, in the vasodilation activity induced by anthocyanins. Methods and results: Vascular reactivity was assessed in thoracic aortic rings obtained from male Wistar rats. Pre-treatment of aortic rings with anti-sequence bilitranslocase antibodies targeting the carrier, decreased vasodilation induced by cyanidin 3-glucoside and bilberry anthocyanins. Conclusion: Here we show for the first time that bilitranslocasemediates a critical step in vasodilation induced by anthocyanins. This offers new insights into the molecular mechanism involved in endothelium-dependent vasorelaxation by flavonoids, and the importance of their specific membrane carriers.
    Source: Nutrition, metabolism and cardiovascular diseases. - ISSN 0939-4753 (Vol. 23, iss. 1, 2013, str. 68-74)
    Type of material - article, component part
    Publish date - 2013
    Language - english
    COBISS.SI-ID - 28168665
    DOI

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