The association between catechol-O-methyl-transferase Val[sup]108/158Met polymorphism and suicide
Pivac, Nela ...
One of the candidate genes for suicide is also a gene in the pathway for catecholamine degradation encoding an enzyme catehol-O-methyl-transferase (COMT). It harbors a common functional polymorphism, ...a G to A nucleotide transition resulting in amino acid substitution from valine (Val) to methionine (Met) at position 158 (COMT Val(108/158) Met; rs4680) that has beenassociated with psychiatric disorders characterized with an increased riskof suicidal behavior. We have performed the first study on Caucasian population examining the association between completed suicide and the COMT Val(108/158) Met polymorphism. The study population consisted of 356 suicide victims and 198 control subjects. Significant difference in COMT Val(108/158) Met variants (genotypes, alleles and Val carriers) distribution was found only in male groups, between controls and suicide victims (p = 0.018; p = 0.031; p = 0.005), and between controls and violent suicide victims (p = 0.026; p = 0.042; p = 0.010). The R value from the standardized residuals revealed that the Met/Met genotype (R = 2.03) in the control group contributedto these significant differences. In contrast to male subjects, no significant differences in the frequency of the COMT Val(108/158) Met variantswere detected between female control and female suicide groups; however the POC (range 0.161-0.680) was below the desired 0.800. In addition, the logistic regression analysis confirmed these significant differences. In conclusion, our results showed the over-presentation of the Met/Met genotype in male control subjects compared to male suicide victims, suggesting that this genotype of the COMT Val(108/158) Met might be a protective factor against suicide.
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