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  • Antibiotic combinations with daptomycin for treatment of staphylococcus aureus infections [Elektronski vir]
    Nadrah, Kristina ; Strle, Franc, 1949-
    Daptomycin is a lipopeptide antibiotic with a unique mechanism of action on Gram-positive bacteria. It is approved for treatment of skin and soft-tissue infections with Gram-positive bacteria, ... bacteraemia and right-sided infectiveendocarditis caused by Staphylococcus aureus. Diminishing susceptibility of S. aureus to daptomycin during treatment of complicated infections and clinical failure have been described. Combinations of daptomycin with other antibiotics including gentamicin, rifampin, beta-lactams, trimethoprim/sulfamethoxazole (TMP-SMX), or clarithromycin present a new approach for therapy. In vitro and animal studies have shown that such combinations may, in some cases, be superior to daptomycin monotherapy. In this paper we focus on the antibiotic combinations for complicated S. aureus infections.
    Source: Chemotherapy Research and Practice (Online). - ISSN 2090-2115 (Vol. [3], 2011, str. [1-10], art. ID 619321)
    Type of material - e-article
    Publish date - 2011
    Language - english
    COBISS.SI-ID - 28314073

    Link(s):

    http://www.hindawi.com/journals/chrp/2011/619321/cta
    DOI

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