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  • 3D QSAR study, synthesis and in vitro evaluation of (+)-5-FBVM as potential PET radioligand for the Vesicular AcetylCholine Transporter (VAChT)
    Kovač, Mitja, farmacevt, 1980- ...
    Located in presynaptic cholinergic nerve terminals, the vesicular acetylcholine transporter (VAChT) represents a potential target for quantitative visualization of early degeneration of cholinergic ... neurons in Alzheimer s disease using PET. Benzovesamicol derivatives are proposed as radioligands for this purpose. We report QSAR studies of vesamicol and benzovesamicol derivatives taking into account the stereoselectivity of the VAChT binding site. Use of different data sets and different models in this study revealed that both enantiomers of 5-fluoro-3-(4-phenyl-piperidin-1-yl)-1,2,3,4-tetrahydro-naphthalen-2-ol (5-FBVM) are promising candidates, with predicted VAChT affinities between 6.1and 0.05 nM. The synthesis of enantiopure (R,R)- and (S,S)-5-FBVM and their corresponding triazene precursors for future radiofluorination is reported. Both enantiomers exhibited high in vitro affinity for VAChT [(+)-5-FBVM: Ki = 6.95 nM and (-)-5-FBVM: Ki = 3.68 nM] and were selective for?2 receptors (not, vert, similar70-fold), only (+)-5-FBVM is selective for ?1 receptors (not, vert, similar5-fold). These initial results suggest that (+)-(S,S)-5-FBVM warrants further investigation as a potential radioligand forin vivo PET imaging of cholinergic nerve terminals.
    Source: Bioorganic & Medicinal Chemistry. - ISSN 0968-0896 (Vol. 18, issue 21, 2010, str. 7659-7667)
    Type of material - article, component part
    Publish date - 2010
    Language - english
    COBISS.SI-ID - 2843249

    Link(s):

    http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6TF8-50T41FH-2&_user=4776866&_coverDate=08%2F17%2F2010&_rdoc=1&_fmt=high&_orig=search&_origin=search&_sort=d&_docanchor=&view=c&_searchStrId=1462852332&_rerunOrigin=google&_acct=C000033658&_version=1&_urlVersion=0&_userid=4776866&md5=7a24ffb1e54dd144f2dc5b42f612ad09&searchtype=a
    DOI

source: Bioorganic & Medicinal Chemistry. - ISSN 0968-0896 (Vol. 18, issue 21, 2010, str. 7659-7667)
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