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Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal - involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1Košir, Rok, 20. 07. 1982 ...Cytochromes P450 Cyp51, 11a1, 17a1, 11b1, 11b2 and 21a1 participate in the adrenal production of corticosteroids whose circulating levels are circadian. cAMP signaling plays an important role in ... adrenal steroidogenesis. By applyingthe cAMP responsive element modulator (Crem) knockout mice we show that CREM isoforms contribute to circadian expression of steroidogenic CYPs inthe mouse adrenal. Most striking is the CREM dependent hypomethylation of Cyp17a1 promoter at zeitgeber time 12 that resulted in higher Cyp17a1 mRNA and protein expression in the knockout adrenals. Data indicate that products of the Crem gene control the epigenetic repression of Cyp17 in mouse adrenals.Source: Biochemistry, biophysics and structure (Vol. 279, iss. 9, special issue, 2012, str. 1584-1593)Type of material - conference contribution ; adult, seriousPublish date - 2012Language - englishCOBISS.SI-ID - 28865753
Author
Košir, Rok, 20. 07. 1982 |
Prosenc Zmrzljak, Uršula |
Bele, Tanja, 1986- |
Ačimovič, Jure |
Perše, Martina, 1975- |
Majdič, Gregor, 1967- |
Prehn, Cornelia |
Adamski, Jerzy, molekularna biologija |
Rozman, Damjana, 1960-
Topics
Circadian Rhythm |
Cytochrome P-450 |
Adrenal Cortex Hormones |
Cyclic Amp |
RNA, Messenger |
Adrenal Glands |
Secretion |
Steroids |
Metabolism |
Gene Expression |
DNA Methylation |
Corticosterone |
Blood |
Polymerase Chain Reaction |
Cells, Cultured |
Mice, Knockout |
Citokrom P-450 |
RNA, prenašalna |
Dnevni ritem |
Kortikosteroidi |
Ciklični AMP |
Polimerazna, verižna reakcija |
Gensko izražanje |
Nadledvični žlezi |
Kortikosteron |
DNA, metilacija |
Celične kulture |
Miši Knockout |
Steroidi
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Košir, Rok, 20. 07. 1982 | 29321 |
Prosenc Zmrzljak, Uršula | 28382 |
Bele, Tanja, 1986- | 34542 |
Ačimovič, Jure | 28352 |
Perše, Martina, 1975- | 23082 |
Majdič, Gregor, 1967- | 13330 |
Prehn, Cornelia | ![]() |
Adamski, Jerzy, molekularna biologija | 55378 |
Rozman, Damjana, 1960- | 06013 |
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