Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal - involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1

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Circadian expression of steroidogenic cytochromes P450 in the mouse adrenal - involvement of cAMP-responsive element modulator in epigenetic regulation of Cyp17a1

Košir, Rok, 20. 07. 1982 ...

Cytochromes P450 Cyp51, 11a1, 17a1, 11b1, 11b2 and 21a1 participate in the adrenal production of corticosteroids whose circulating levels are circadian. cAMP signaling plays an important role in ... adrenal steroidogenesis. By applyingthe cAMP responsive element modulator (Crem) knockout mice we show that CREM isoforms contribute to circadian expression of steroidogenic CYPs inthe mouse adrenal. Most striking is the CREM dependent hypomethylation of Cyp17a1 promoter at zeitgeber time 12 that resulted in higher Cyp17a1 mRNA and protein expression in the knockout adrenals. Data indicate that products of the Crem gene control the epigenetic repression of Cyp17 in mouse adrenals.

Source: Biochemistry, biophysics and structure (Vol. 279, iss. 9, special issue, 2012, str. 1584-1593)

Type of material - conference contribution ; adult, serious

Publish date - 2012

Language - english

COBISS.SI-ID - 28865753

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source: Biochemistry, biophysics and structure (Vol. 279, iss. 9, special issue, 2012, str. 1584-1593)

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Year	Impact factor		Edition		Category		Classification
Year	JCR	SNIP	JCR	SNIP	JCR	SNIP	JCR	SNIP

Links to authors' personal bibliographies	Links to information on researchers in the SICRIS system
Košir, Rok, 20. 07. 1982	29321
Prosenc Zmrzljak, Uršula	28382
Bele, Tanja, 1986-	34542
Ačimovič, Jure	28352
Perše, Martina, 1975-	23082
Majdič, Gregor, 1967-	13330
Prehn, Cornelia
Adamski, Jerzy, molekularna biologija	55378
Rozman, Damjana, 1960-	06013

Source: Personal bibliographies and: SICRIS

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