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Glucagon like-peptide-1 receptor is covalently modified by endogenous mono-ADP-ribosyltransferaseDeželak, Matjaž, 1984- ; Bavec, AljošaOur previous study revealed a mono-ADP-ribosyltransferase mediated in vitro mono-ADP-ribosylation of IC(3) peptide, a peptide with sequence corresponded to third intracellular loop of glucagon ... like-peptide-1 (GLP-1) receptor. Furthermore, Arg(348) was shown to be modified amino acid residue although itsmutation did not eliminate mono-ADP-ribosylation completely. In order to further study the signaling mechanisms of GLP-1 receptor, we took on lease a possibility that an alternative site of enzymatic modification exist so mono-ADP-ribosylation of Cys(341) was hypothesized. The results confirmed bothArg(348) and Cys(341) as a site of mono-ADP-ribosylation where Arg(348) ismodified predominantly. Sum of mono-ADP-ribosylation rate of both single IC(3) mutants coincided with IC(3) rate. What is in vivo role of Cys(341) mono-ADP-ribosylation is entirely speculative but our study represents an important step toward a complete understanding of signaling via GLP-1 receptor.Source: Molecular biology reports. - ISSN 0301-4851 (Vol. 39, no. 4, 2012, str. 4375-4381)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 29195993
Author
Deželak, Matjaž, 1984- |
Bavec, Aljoša
Topics
Glucagon |
Receptors, Glucagon |
Cho Cells |
Nad+ Adp-Ribosyltransferase |
Nad(P)(+)-Arginine Adp-Ribosyltransferase |
Translation, Genetic |
Immunoblotting |
Diabetes Mellitus |
NAD+ ADP-riboziltransferaza |
CHO celice |
Glukagon |
Receptorji glukagonski |
NAD(P)(+)-arginin ADP-riboziltransferaza |
Translakcija genetična |
Imunoblot |
Sladkorna bolezen
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Deželak, Matjaž, 1984- | 33104 |
Bavec, Aljoša | 16130 |
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