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Stress-free state of the red blood cell membrane and the deformation of its skeletonŠvelc, Tjaša, biofizika, 1983- ; Svetina, Saša, 1935-The response of a red blood cell (RBC) to deformation depends on its membrane,a composite of a lipid bilayer and a skeleton, which is a closed, twodimensional network of spectrin tetramers as its ... bonds. The deformation of the skeleton and its lateral redistribution are studied in terms of the RBC resting state for a fixed geometry of the RBC, partially aspirated into a micropipette. The geometry of the RBC skeleton in its initial state is taken to be either two concentric circles, a references biconcave shape or a sphere.It is assumed that in its initial state the skeleton is distributed laterally in a homogeneous manner with its bonds either unstressed, presenting its stress-free state, or prestressed. The lateral distribution wascalculated using a variational calculation. It was assumed that the spectrin tetramer bonds exhibit a linear elasticity. The results showed a significant effect of the initial skeleton geometry on its lateral distribution in the deformed state. The proposed model is used to analyze the measurements of skeleton extension ratios by the method of applying two modes of RBC micropipette aspiration.Source: Cellular & molecular biology letters : an international journal : cellular membranes, cytoskeleton, nuclear architecture, gene expression, biomolecular interactions, biotechnology. - ISSN 1425-8153 (Vol. 17, iss. 2, 2012, str. 217-227)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 29543897
Author
Švelc, Tjaša, biofizika, 1983- |
Svetina, Saša, 1935-
Topics
Biophysics |
Erythrocyte Membrane |
Erythrocyte Deformability |
Erythrocyte Indices |
Spectrin |
Lipid Bilayers |
Models, Theoretical |
Eritrociti, deformabilnost |
Eritrocitna membrana |
Spektrin |
Biofizika |
Eritrociti, značilnosti |
Lipidna, dvojna plast |
Modeli teoretski
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Švelc, Tjaša, biofizika, 1983- | 33183 |
Svetina, Saša, 1935- | 02013 |
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