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Upregulation of DNA sensors in B16.F10 melanoma spheroid cells after electrotransfer of pDNA [Elektronski vir]Žnidar, Katarina ...Increased expression of cytosolic DNA sensors, a category of pattern recognition receptor, after control plasmid DNA electrotransfer was observed in our previous studies on B16.F10 murine melanoma ... cells. This expression was correlated with the upregulation of proinflammatory cytokines and chemokines and was associated with cell death. Here, we expanded our research to include the influence of features of cells in a 3-dimensional environment, which better represents the tumors% organization in vivo. Our results show that lower number of cells were transfected in spheroids compared to 2-dimensional cultures, that growth was delayed after electroporation alone or after electrotransfer of plasmid DNA, and that DNA sensors DDX60, DAI/ZBP1, and p204 were upregulated 4 hours and 24 hours after electrotransfer of plasmid DNA. Moreover, the cytokines interferon % and tumor necrosis factor % were also upregulated but only 4 hours after electrotransfer of plasmid DNA. Thus, our results confirm the results obtained in 2-dimensional cell cultures demonstrating that electrotransfer of plasmid DNA to tumor cells in spheroids also upregulated cytosolic DNA sensors and cytokines.Source: Technology in cancer research and treatment [Elektronski vir]. - ISSN 1533-0338 (Vol. 17, 2018, str. 1-9)Type of material - e-articlePublish date - 2018Language - englishCOBISS.SI-ID - 2966139
Author
Žnidar, Katarina |
Omerzel, Maša, mag. farm. |
Jesenko, Tanja |
Heller, Loree C. |
Čemažar, Maja
Topics
melanom |
sferoidi |
senzorji DNK |
interferon beta |
melanoma |
spheroids |
DNA sensors |
interferon
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Žnidar, Katarina | 37534 |
Omerzel, Maša, mag. farm. | 34373 |
Jesenko, Tanja | 33227 |
Heller, Loree C. | |
Čemažar, Maja | 14575 |
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