-
High fat mixed lipid diet modifies protective effects of exercise on 1,2 dimethylhydrazine induced colon cancer in rats [Elektronski vir]Perše, Martina, 1975- ...The aim of the present study was to evaluate the effect of long-term swimming exercise in conjunction with a high fat mixed lipid (HFML) diet on colon cancer (CC) development and lipid peroxidation ... in the large bowel. We used forty male Wistar rats, which were randomly divided into one control group andfour cancer groups: sedentary and swimming groups fed a standard diet (LFCO) and sedentary and swimming groups fed an HFML diet. Corticosterone was determined during the experiment. After 6 months of swimming, the rats were sacrificed and blood, heart, liver, muscle and large bowel were taken for determining the activity of serum enzymes, antioxidant capacity and CC development. The results demonstrate that exercise has a protective role in CCdevelopment. Attenuated development of CC and increased levels of malondialdehyde (MDA) in the large bowel of exercised rats show that one of the protective effects of exercise on developing CC is induction of oxidative stress. However, in terms of the combined effects of dietary fat and exercise,our results indicate that the protective role of exercise on CC development is significantly depressed by an HFML diet. An HFML diet significantly reduced the protective influence of exercise on colon carcinogenesis in rats and affected the degree of peroxidation in the large bowel during exercise, as well as concentrations of serum enzymes (LDH, alpha-HBDH, CK, ALT and AST). Our results indicate that an HFML diet, which reflects the composition of a Western style diet, is a significant modifier ofthe protective effects of exercise on CC development in rats.Source: Technology in cancer research and treatment [Elektronski vir]. - ISSN 1533-0338 (Vol. 11, no. 3, 2012, str. 289-299)Type of material - e-articlePublish date - 2012Language - englishCOBISS.SI-ID - 29671641
Author
Perše, Martina, 1975- |
Injac, Rade |
Štrukelj, Borut |
Cerar, Anton, 1945-
Topics
Colonic Neoplasms |
Chemically Induced |
Dimethylhydrazines |
Exercise |
Dietary Fats |
Oxidative Stress |
Lipid Peroxidation |
Corticosterone |
Malondialdehyde |
Weight Gain |
Rats, Wistar |
Dimetilhidrazini |
Telesna vadba |
Debelo črevo, novotvorbe |
Dietne maščobe |
Oksidativni stres |
Podgane, Wistar |
Lipidna peroksidacija |
Malondialdehid |
Kortikosteron |
Teža, pridobivanje
![loading ... loading ...](themes/default/img/ajax-loading.gif)
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Perše, Martina, 1975- | 23082 |
Injac, Rade | 30616 |
Štrukelj, Borut | 07849 |
Cerar, Anton, 1945- | 05367 |
Select pickup location:
Material pickup by post
Notification
Subject headings in COBISS General List of Subject Headings
Select pickup location
Pickup location | Material status | Reservation |
---|
Please wait a moment.