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Radiation-induced carotid artery lesionsFernández-Alvarez, Verónica ...To review the current aspects of knowledge related to the risk of cerebrovascular events in patients receiving head and neck radiotherapy. METHODS: A literature search was performed in PubMed. Papers ... meeting selection criteria were reviewed. RESULTS: We provide an update on the problem by identifying key studies that have contributed to our current understanding of the epidemiology, radiologic features, pathogenesis, and treatment of the disease. The incidence of carotid artery stenosis ranged from 18 to 38% in patients who underwent radiotherapy for head and neck cancer versus from 0 to 9.2% among the nonirradiated patients. Neck irradiation increases the intima-media thickness of the carotid artery wall. These changes are the earliest visible alteration in the carotid wall and are also detected with color Doppler ultrasonography. Endovascular treatment with a carotid angioplasty and stenting is the first-line treatment for most symptomatic patients. CONCLUSIONS: Radiation-induced atherosclerosis is a different and accelerated form of atherosclerosis, which implies a more aggressive disease with a different biologic behavior. The disease is characterized by a high rate of carotid artery stenosis compared to those observed in nonirradiated control group patients. To prevent the risk of stroke, surveillance and imaging with ultrasonography should enable detection of severe stenosis. Endovascular treatment with a carotid angioplasty and stenting has been proposed as an attractive and minimally invasive alternative for some radiation-induced stenoses.Source: Strahlentherapie und Onkologie. - ISSN 0179-7158 (Vol. 194, iss. 8, 2018, str. 699-710)Type of material - article, component partPublish date - 2018Language - englishCOBISS.SI-ID - 2969979
Author
Fernández-Alvarez, Verónica |
López, Fernando, zdravnik |
Suárez, Carlos, zdravnik |
Strojan, Primož |
Eisbruch, Avraham |
Silver, Carl E. |
Mendenhall, William M. |
Langendijk, Johannes A. |
Rinaldo, Alessandra |
Lee, Anne W. M.
Topics
radioterapija |
obsevanje |
arterijske lezije |
glava in vrat |
radiotherapy |
artery lesions |
head and neck
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Fernández-Alvarez, Verónica | |
López, Fernando, zdravnik | |
Suárez, Carlos, zdravnik | |
Strojan, Primož | 14576 |
Eisbruch, Avraham | |
Silver, Carl E. | |
Mendenhall, William M. | |
Langendijk, Johannes A. | |
Rinaldo, Alessandra | |
Lee, Anne W. M. |
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