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Development and pharmacokinetic evaluation of erythromycin lipidic formulations for oral administration in rainbow trout (Oncorhynchus mykiss)Serdoz, Francesca ...The aim of this work was to enhance the bioavailability of erythromycin base when administered orally in rainbow trout (Oncorhynchus mykiss). Since erythromicin is normally given in the form of ... medicated feed, in this study 3 new types of feed formulation were developed. A self-emulsifying system and two types of double microemulsions (O/W/O) were prepared, characterised and adsorbed on a commercial extruded diet for fish. The emulsified systems were based on saturated polyglycolized glycerides and mono- and diglycerides of medium chain fatty acids (as oily phase), Tweenr 80 (as surfactant) and, in the case of double microemulsions, distilled water. The systems differed in percentage composition and for the amount and position of erythromycin in different phases. The three medicated feed were then administered orally by means of a gastric probe to rainbow trout and their relative bioavailability was estimated in comparison to that obtained after oral administration of feed with erythromycin powder. For each medicated feed, 80 fish were tested. Finally, plasma profiles of erythromycin after single administration of medicated feeds were used to predict profiles obtainable by administering once daily medicated feeds for 7 consecutive days. The results proved that the feeds containing microemulsified erythromycin provided largely superior oral bioavailability and the advantage of obtaining the same efficacy against bacterial infections with a much lower dose of drug.Source: European journal of pharmaceutics and biopharmaceutics. - ISSN 0939-6411 (Vol. 78, no. 3, 2011, str. 401-407)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 2975089
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DOI
Author
Serdoz, Francesca |
Voinovich, Dario |
Perissutti, Beatrice |
Grabnar, Iztok |
Hasa, Dritan |
Ballestrazzi, Rodolfo |
Coni, Ettore |
Pellegrini, Enrico
Topics
eritromicin |
farmakokinetika |
mikroemulzije |
akvakultura
source: European journal of pharmaceutics and biopharmaceutics. - ISSN 0939-6411 (Vol. 78, no. 3, 2011, str. 401-407)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Serdoz, Francesca | |
Voinovich, Dario | |
Perissutti, Beatrice | |
Grabnar, Iztok | 16107 |
Hasa, Dritan | |
Ballestrazzi, Rodolfo | |
Coni, Ettore | |
Pellegrini, Enrico |
Source: Personal bibliographies
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