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Predictive value of ABCB1 polymorphisms G2677T/A, C3435T, and their haplotype in small cell lung cancer patients treated with chemotherapyKnez, Lea, 1981- ...Purpose: Multiple drug resistance limits the efficacy of numerous cytotoxic drugs used in the treatment of small cell lung cancer (SCLC). The drug efflux protein ATP-binding cassette transporter B1 ... (ABCB1) has an important role in this process, and its gene variability may affect chemotherapy outcomes. Patients and methods: This study aimed to evaluate the associations between ABCB1 polymorphisms G2677T/A, C3435T, and their haplotype with progression-free survival (PFS) and overall survival (OS) in 177 SCLC patientstreated with cisplatin-etoposide or cyclophosphamide-epirubicin-vincristine chemotherapy. To determine the ABCB1 genotype, allelic specific TaqMan((R)) probes were used in a RT-PCR . RESULTS: Patients carrying the G2677T/A TT + TA + AA genotypes (24 %) or the C3435T CT + TT genotypes (72 %) or the 2677T/A-3435T haplotype (40 %) had a longer PFS (Cox regression, P = 0.052, 0.037 and 0.037, respectively); these associations persisted also in multivariate analyses (Cox regression, P = 0.028, 0.037 and 0.030, respectively). Moreover, patients with the C3435T CT + TT genotypes had a longer OS both in univariate and multivariate analysis (Cox regression, P = 0.022 and 0.028, respectively). A trend toward longer OS was noted for the 2677T/A-3435T haplotype (Cox regression, P = 0.051), but itsindependent value was not confirmed (Cox regression, P = 0.071). Conclusions: Our study reported a possible predictive value of ABCB1 polymorphisms G2677T/A, C3435T, and their haplotype for longer PFS and OS in Caucasian SCLC patients treated with chemotherapy. However, to be implemented into routine clinical practice, ABCB1 polymorphisms require further validation.Source: Journal of cancer research and clinical oncology. - ISSN 0171-5216 (Vol. 138, iss. 9, 2012, str. 1551-1560)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 29829337
Author
Knez, Lea, 1981- |
Košnik, Mitja |
Ovčariček, Tanja |
Sadikov, Aleksander, računalništvo |
Sodja, Eva |
Kern, Izidor |
Čufer, Tanja, 1955-
Topics
Lung Neoplasms |
Diagnosis |
Drug Therapy |
Genetics |
Carcinoma, Small Cell |
Polymorphism (Genetics) |
Predictive Value Of Tests |
Drug Resistance, Multiple |
Genotype |
Immunohistochemistry |
Survival Analysis |
Polimorfizem (genetika) |
Pljučne novotvorbe |
Karcinom drobnocelični |
Napovedna vrednost testov |
Mnogozdravilna rezistenca |
Preživetje, analiza |
Imunohistokemija |
Genotip
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Knez, Lea, 1981- | 29281 |
Košnik, Mitja | 10921 |
Ovčariček, Tanja | 54060 |
Sadikov, Aleksander, računalništvo | 20389 |
Sodja, Eva | 28517 |
Kern, Izidor | 15781 |
Čufer, Tanja, 1955- | 12179 |
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