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Cathepsin X cleavage of the ß2 integrin regulates talin-binding and LFA-1 affinity in T cellsJevnikar, Zala ...T cell migration, essential for immune surveillance and response, is mediated by the integrin LFA-1. CatX, a cysteine carboxypeptidase, is involved in the regulation of T cell migration by ... interaction with LFA-1. We show that sequential cleavage of C-terminal amino acids from the ?2 cytoplasmic tail of LFA-1, by CatX, enhances binding of the adaptor protein talin to LFA-1 and triggers formation of the latter's high-affinity form. As shown by SPR analysis of peptides constituting the truncated ?2 tail, the cleavage of three C-terminal amino acids by CatX resulted in a 1.6-fold increase of talin binding. Removal of one more amino acid resulted in a 2.5-fold increase over the intact tail. CatX cleavage increased talin-binding affinity to the MD but not the MP talin-binding site on the ?2 tail. This was shown by molecular modeling of the ?2 tail/talin F3 complex to be a result of conformational changes affecting primarily the distal-binding site. Analysis of LFA-1 by conformation-specific mAb showed that CatX modulates LFA-1 affinity, promoting formation of high-affinity from intermediate-affinity LFA-1 but not the initial activation of LFA-1 from a bent to extended form. CatX post-translational modifications may thus represent a mechanism of LFA-1 fine-tuning that enables the trafficking of T cellsSource: Journal of leukocyte biology. - ISSN 0741-5400 (Vol. 90, no. 1, 2011, str. 99-109)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 2988913
Author
Jevnikar, Zala |
Obermajer, Nataša |
Doljak, Bojan |
Turk, Samo |
Gobec, Stanislav, 1970- |
Švajger, Urban |
Hailfinger, Stephan |
Thome, Margot |
Kos, Janko, 1959-
Topics
katepsin X |
T celice |
LFA-1 |
ß2 integrin
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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DRS, in which the journal is indexed
Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jevnikar, Zala | 26497 |
Obermajer, Nataša | 25494 |
Doljak, Bojan | 19785 |
Turk, Samo | 29773 |
Gobec, Stanislav, 1970- | 15284 |
Švajger, Urban | 26198 |
Hailfinger, Stephan | |
Thome, Margot | |
Kos, Janko, 1959- | 04648 |
Source: Personal bibliographies
and: SICRIS
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