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Priprava protitumorskih cepiv na osnovi dendritičnih celic = Generation of dendritic cells as cancer vaccinesObermajer, NatašaOdkritje s tumorjem-povezanih antigenov, ki jih bodisi selektivno ali preferečno izražajo tumorji, s sočasnim poglobljenim znanjem ključne vloge dendritičnih celic (DC) v imunskem sistemu, je ... postavilo temelje za pričetek imunoterapije raka na osnovi DC. 29. aprila 2010 je FDA odobrila Provenge (sipuleucel-T) kot prvo avtologno celično imunoterapijo za zdravljenje asimptomatskega ali minimalno simptomatskega metastaznega ter kastratno rezistentnega (hormonsko-refraktorni) raka prostate. Kljub temu so terapije z uporabo DC že na začetku razvoja, saj se metode, ki omogočajo pripravo DC, ki so sposobne učinkovito predstavljati tumorske antigene, ter izboljšanja njihovih imunostimulatornih funkcij neprestano optimizirajo. Poleg tega je nedavno izboljšanje spremljanja imunskih odzivov nakazalo potrebo po pazljivem načrtovanju tega dela kliničnih preizkušanj. Kljub temu obstajajo številni dokazi, ki podpirajo uporabo DC v kliničnih terapijah. V tem članku je predstavljen razvoj pridobivanja DC primernih za klinično rabo, metode obdelave DC s tumorskimi antigeni ter pristopi spremljanja imunskih odzivov pri terapiji s cepivi na osnovi DC.Source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 62, št. 1, apr. 2011, str. 9-14)Type of material - article, component partPublish date - 2011Language - slovenianCOBISS.SI-ID - 2999409
Author
Obermajer, Nataša
Topics
dendritične celice |
protitumorska cepiva |
rak |
imunoterapija |
celice T
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source: Farmacevtski vestnik : strokovno glasilo slovenske farmacije = pharmaceutical journal of Slovenia. - ISSN 0014-8229 (Letn. 62, št. 1, apr. 2011, str. 9-14)
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Obermajer, Nataša | 25494 |
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