ALL libraries (COBIB.SI union bibliographic/catalogue database)
13.
DNA repair polymorphisms influence the risk of second neoplasm after treatmentof childhood acute lymphoblastic leukemia
Erčulj, Nina ...
Purpose: Patients treated for childhood acute lymphoblastic leukemia (ALL) areconsidered to be at increased risk of developing second neoplasm. The aim of our study was to identify DNA repair ...polymorphisms contributing to the risk of second neoplasm in clinically well-characterized Slovenian patients treated for childhood ALL. Methods: Pediatric patients diagnosed with ALL between 1971 and 2001 were included in the study. According to the identified clinical risk factors for second neoplasm, a matched set of cases with second neoplasm and controls was selected and genotyped for 11 DNA repair polymorphisms. Results: Among 359 pediatric patients with ALL, 20 second neoplasms were observed. The dose of radiotherapy (P = 0.011), administration of epipodophyllotoxins (P = 0.006), and the dose of anthracyclines (P < 0.001)showed a significant association with the risk of second neoplasm. Amonggenetic factors, we observed a significant association of NBN 1197G allele with increased risk of second neoplasms (RR = 4.36; 95 % CI: 1.19-15.98; P = 0.026), while the risk was decreased in carriers of XRCC3-316Gallele compared with patients with wild-type genotype (RR = 0.20; 95 % CI: 0.04-0.99; P = 0.049). Conclusions: Our results suggest an important role of NBN 1197A>G and XRCC3-316A>G polymorphisms in the development of second neoplasm in patients treated for childhood ALL.
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