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Impact of ERCC1 expression on treatment outcome in small-cell lung cancer patients treated with platinum-based chemotherapySodja, Eva ...Introduction: The excision repair cross-complementing 1 (ERCC1) protein is an extensively investigated molecular marker because it may decrease sensitivity to platinum-based chemotherapy. Low ERCC1 ... expression has already been correlated with better treatment efficacy in non-small-cell lung cancer patients treated with platinum-based chemotherapy. However, the data on a prognostic and/or predictive value of ERCC1 in small-cell lung cancer (SCLC) are still very limited. Methods: This retrospective pilot study evaluated the impact of ERCC1 expression levels on response to first-line platinum-based chemotherapy with or without radiotherapy and survival outcomes of 77 SCLC patients. ERCC1 protein expression was determined immunohistochemically in primary tumour tissue. Results: ERCC1 protein expression was positive in 40/77(51.9%) of our patients. No significant association was found between ERCC1 protein expression and response rate to first-line platinum-based chemotherapy, progression-free survival (PFS), or overall survival (OS), either in the overall population or in patients stratified by disease stage. Conclusions: In our limited group of 77 SCLC patients, ERCC1 protein expression was not found to correlate with either response rate to platinum-based chemotherapy or survival outcomes. Multi-centric prospective trials using a validated method of ERCC1 determination are mandatory in orderto obtain a definitive answer on the predictive value of ERCC1 in SCLC.Source: European Journal of Cancer. - ISSN 0959-8049 (Vol. 48, iss. 18, 2012, str. 3378-3385)Type of material - article, component part ; adult, seriousPublish date - 2012Language - englishCOBISS.SI-ID - 30115033
Author
Sodja, Eva |
Knez, Lea, 1981- |
Kern, Izidor = Kern, Izidor |
Sadikov, Aleksander, računalništvo |
Čufer, Tanja, 1955-
Topics
Lung Neoplasms |
Drug Therapy |
Carcinoma, Small Cell |
Platinum |
Tumor Markers, Biological |
Immunohistochemistry |
Treatment Outcome |
Survival Analysis |
Tumorski označevalci biološki |
Imunohistokemija |
Pljučne novotvorbe |
Karcinom drobnocelični |
Platina |
Preživetje, analiza |
Zdravljenje, izid
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Sodja, Eva | 28517 |
Knez, Lea, 1981- | 29281 |
Kern, Izidor = Kern, Izidor | 15781 |
Sadikov, Aleksander, računalništvo | 20389 |
Čufer, Tanja, 1955- | 12179 |
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