ALL libraries (COBIB.SI union bibliographic/catalogue database)
  • Design and synthesis of new hydroxyethylamines as inhibitors of D-alanyl-D-lactate ligase (VanA) and D-alanyl-D-alanine ligase (DdlB)
    Sova, Matej, 1979- ...
    The Van enzymes are ATP-dependant ligases responsible for resistance to vancomycin in Staphylococcus aureus andEnteroccoccus species. The de novo molecular design programme SPROUT was used in ... conjunction with the X-ray crystal structure of Enterococcus faecium D-alanyl-D-lactate ligase (VanA) to design new putative inhibitors based on a hydroxyethylamine template. The two best ranked structures were selected and efficient syntheses developed. The inhibitory activities of these molecules were determined on E. faecium VanA, and due to structural similarity and a common reaction mechanism, also on D-Ala-D-Ala ligase (DdlB) from Escherichia coli. The phosphate group attached to the hydroxyl moiety of the hydroxyethylamine isostere within these systems is essential for their inhibitory activity against both VanA and DdlB.
    Source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 19, no. 5, 2009, str. 1376-1379)
    Type of material - article, component part
    Publish date - 2009
    Language - english
    COBISS.SI-ID - 30127109
    DOI

Shelf entry