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Angiogenin and vascular endothelial growth factor expression in lungs of lung cancer patientsRozman, Aleš, 1973- ; Šilar, Mira ; Košnik, MitjaBackground. Lung cancer is the leading cause of cancer deaths. Angiogenesis iscrucial process in cancer growth and progression. This prospective study evaluated expression of two central regulatory ... molecules: angiogenin and vascular endothelial growth factor (VEGF) in patients with lung cancer. Patients and methods. Clinical data, blood samples and broncho-alveolar lavage(BAL) from 23 patients with primary lung carcinoma were collected. BAL fluid was taken from part of the lung with malignancy, and from corresponding healthy side of the lung. VEGF and angiogenin concentrations were analysed by an enzyme-linked immunosorbent assay. Dilution of bronchial secretions in the BAL fluid was calculated from urea concentration ratio between serum and BAL fluid. Results. We found no statistical correlation between angiogenin concentrations in serum and in bronchial secretions from both parts of the lung. VEGF concentrations were greater in bronchial secretions in the affectedside of the lung than on healthy side. Both concentrations were greater than serum VEGF concentration. VEGF concentration in serum was in positive correlation with tumour size (p = 0,003) and with metastatic stage ofdisease (p = 0,041). There was correlation between VEGF and angiogenin concentrations in bronchial secretions from healthy side of the lung and between VEGF and angiogenin concentrations in bronchial secretions from part of the lung with malignancy. Conclusion. Angiogenin and VEGF concentrations insystemic, background and local samples of patients with lung cancer are affected by different mechanisms. Pro-angiogenic activity of lung cancer has an important influence on the levels of angiogenin and VEGF.Source: Radiology and oncology. - ISSN 1318-2099 (Vol. 46, no. 4, dec. 2012, str. 354-359, VII)Type of material - article, component part ; adult, seriousPublish date - 2012Language - englishCOBISS.SI-ID - 30200537
Author
Rozman, Aleš, 1973- |
Šilar, Mira |
Košnik, Mitja
Topics
Lung Neoplasms |
Angiogenesis Factor |
Endothelial Growth Factors |
Endothelium, Vascular |
Bronchoalveolar Lavage Fluid |
Prospective Studies |
Bronhoalveolarni izpirek, tekočina |
Endotelij žilni |
Pljučne novotvorbe |
Endotelijski, rastni faktorji |
Angiogenetski faktor |
Prospektivne študije
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Database name | Field | Year |
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Rozman, Aleš, 1973- | 25177 |
Šilar, Mira | 25331 |
Košnik, Mitja | 10921 |
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