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Short-term venom immunotherapy induces desensitization of Fc[epsilon]RI-mediated basophil response
Čelesnik Smodiš, Nina ...
Background: The precise immunological mechanisms for the early clinical protection of venom immunotherapy (VIT) have not yet been explained. Our aim was to evaluate whether high-affinity IgE receptor ...(FcepsilonRI) and the related basophil function have a role in the induction of short-term VIT protection. Methods: We included 60 adults and 48 children. Basophil thresholdsensitivity (CD-sens) to anti-FcepsilonRI stimulation, and FcepsilonRI gene and cell-surface expression were assessed at the beginning and just before the first maintenance dose (MD) of 100 mug of ultra-rush VIT (day 5) and at the beginning, during buildup, and just before the first MD of 70 mug and of 100 mug of semi-rush VIT (weeks 1-2 and 5). Results: We demonstrated a significant reduction in CD-sens to anti-FcepsilonRI stimulation before the first MD in both ultra-rush and semi-rush VIT in all included subjects. FcepsilonRI gene and/or cell-surface expression was decreased in 34-100% of subjects, with different dynamics between VIT protocols. Conclusion: We found a marked desensitization of FcepsilonRI-activated basophils after short-term VIT. This suppression, whichcould be highly relevant for the development of early protective mechanisms, might be also related to the changes at the level of FcepsilonRI expression.
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