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Disturbed balance between phase I and II metabolizing enzymes in ovarian endometriosis : a source of excessive hydroxy-estrogens and ROS?Hevir-Kene, Neli ; Ribič-Pucelj, Martina ; Lanišnik-Rižner, TeaOxidative metabolism of estrogens was studied in 31 ovarian endometriosis and 29 normal endometrium samples, by qPCR. Expression was monitored for genes encoding five estrogen hydroxylating, five ... hydroxy (OH)-estrogen conjugating, and three estrogen quinone detoxifying enzymes. CYP1B1, COMT, NQO1, and GSTP1 protein levels were determined using Western blotting and immunohistochemistry staining. Increased expression of CYP1A1, CYP3A7 and COMT, and higher levels of MB-COMT were seen in endometriosis, as compared to normal endometrium. Expression of CYP1B1, CYP3A5, SULT1A1 and NQO2 was unchanged, with comparable CYP1B1 protein levels. Expression of SULT1E1, SULT2B1, UGT2B7, NQO1, and GSTP1 was decreased. Three NQO1 isoforms were detected; NQO1c appears to be endometriosis-specific. Our data indicate a disturbed balance between phase I and II metabolizing enzymes in endometriosis, potentially leading to excessive OH-estrogen and altered ROS formation, and stimulation of proliferation of ectopic endometrium. This is the first report on disturbed expression of estrogen oxidative metabolism genes in ovarian endometriosisSource: Molecular and cellular endocrinology. - ISSN 0303-7207 (Vol. 367, iss. 1/2, str. 74-84)Type of material - article, component part ; adult, seriousPublish date - 2013Language - englishCOBISS.SI-ID - 30367193
Author
Hevir-Kene, Neli |
Ribič-Pucelj, Martina |
Lanišnik-Rižner, Tea
Topics
citokrom P450 (CYP) |
estrogeni |
metabolizem |
encimi
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Hevir-Kene, Neli | 29240 |
Ribič-Pucelj, Martina | 05274 |
Lanišnik-Rižner, Tea | 11699 |
Source: Personal bibliographies
and: SICRIS
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