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PKC phosphorylates HEXIM1 and regulates P-TEFb activityFujinaga, Koh ...The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 ... binds to 7SK snRNA and recruits as well as inactivates P-TEFb in the 7SK snRNP. Several stimuli can affect this P-TEFb equilibrium. In this study, we demonstrate that protein kinase C (PKC) phosphorylates the serine at position158 (S158) in HEXIM1. This phosphorylated HEXIM1 protein neither binds to 7SK snRNA nor inhibits P-TEFb. Phorbol esters or the engagement of the T cell antigen receptor, which activate PKC and the expression of the constitutively active (CA) PKC? protein, which is found in T cells, inhibit the formation of the 7SK snRNP. All these stimuli increase P-TEFb-dependent transcription. In contrast, the kinase-negative PKC? and the mutant HEXIM1 (S158A) proteins block effects of these PKC-activating stimuli. These results indicate that the phosphorylation of HEXIM1 by PKC represents a major regulatory step of P-TEFb activity in cells.Source: Nucleic acids research. - ISSN 0305-1048 (Vol. 40, no. 18, 2012, str. 9160-9170)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 30560729
Author
Fujinaga, Koh |
Barborič, Matjaž, 1975- |
Li, Qintong |
Luo, Zeping |
Peterlin, Matija Boris |
Price, David H.
Topics
polymerase |
transcription |
cell antigen |
polimeraza |
transkripcija |
celični antigen
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Fujinaga, Koh | ![]() |
Barborič, Matjaž, 1975- | 20346 |
Li, Qintong | ![]() |
Luo, Zeping | ![]() |
Peterlin, Matija Boris | 34721 |
Price, David H. | ![]() |
Source: Personal bibliographies
and: SICRIS
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