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Thrombin inhibitors with lipid peroxidation and lipoxygenase inhibitory activitiesIlić, Miloš ...Vascular oxidative stress, endothelial injury and thrombosis are intertwined processes that display a synergistic pathological effect in many cardiovascular diseases. Antithrombotic therapy with ... anticoagulant and/or antiplatelet agents, combined with interventions against vascular oxidative stress and/or inflammation, both boosting endothelial antithrombotic potential, could display a synergistic action in the treatment of thrombosis. Of the compounds 10a-h and 11a-d, shown to possess thrombin inhibitory activity, 11a-d were found to display radical scavenging activity, 10a, 10d and 10f were demonstrated to inhibit lipid peroxidation of linoleic acid, and 10b and 10h inhibited soybean lipoxygenase. The observed combination of thrombin inhibition with lipid peroxidation and/or lipoxygenase inhibitory activity makes compounds 10 and 11 interesting candidates for further investigations towards multiple antithrombotic drugs.Source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 21, no. 16, 2011, str. 4705-4709)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 3061361
source: Bioorganic & Medicinal Chemistry Letters. - ISSN 0960-894X (Vol. 21, no. 16, 2011, str. 4705-4709)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ilić, Miloš | 35864 |
Kontogiorgos, Christos | |
Hadjipavlou-Litina, Dimitra | |
Ilaš, Janez | 24400 |
Kikelj, Danijel | 01463 |
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