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Opposing effects of dexamethasone, agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cellsRežonja, Katja ; Lorenzon, Paola ; Marš, Tomaž, 1972-Neuromuscular junction development is the key process required for successful neuromuscular transmission and functional innervation of skeletal muscle fibres. Various substances can influence these ... processes, some of which are in common use in clinical practice. In the present study, the effects of the potentially new therapeutic agent agrin were followed, along with the widely used glucocorticoid dexamethasone. The in vitro experimental model used was functional innervation and constitutive interleukin 6 (IL-6) secretion of human muscle cells. Additionally, the selective relaxant binding agent sugammadex and its possible interaction with dexamethasone were followed. Dexamethasone impaired functional innervation while agrin had opposing effects. Furthermore, based on interference with IL-6 secretion, we show potential (chemical) interactions between dexamethasone and sugammadex. The physiological effects of this interaction should be taken into consideration under clinical conditions where these two drugs might be applied simultaneously.Source: Neuroscience letters. - ISSN 0304-3940 (Vol. 549, 9. Aug. 2013, str. 186-190)Type of material - article, component part ; adult, seriousPublish date - 2013Language - englishCOBISS.SI-ID - 30721753
Author
Režonja, Katja |
Lorenzon, Paola |
Marš, Tomaž, 1972-
Topics
neuromuscular junction |
dexamethasone |
interleukin 6 |
nevromišični spoj |
deksametazon |
interlevkin 6
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Režonja, Katja | 37069 |
Lorenzon, Paola | |
Marš, Tomaž, 1972- | 16345 |
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