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Circulating serum sVCAM-1 concentration inadvanced ovarian cancer patients : correlation with concentration in ascitesJakimovska, Marina ...Background. Vascular cell adhesion molecule-1 (VCAM-1) is associated with ovarian cancer progression but theorigin of its soluble form (sVCAM-1) in serum is not well investigated. The purpose of this ... study was to elucidate whetherthe concentration of sVCAM-1 in serum correlates with the concentration in ascites, that represents local tumour environment,and with systemic inflammation, various clinicopathological characteristics, and patient outcome.Patients and methods. Thirty-six patients with advanced ovarian cancer were included in the study. Serum forsVCAM-1 analysis was obtained prior to surgery. Ascites samples were collected at the beginning of the operation.Clinical data were collected from patients medical records. sVCAM-1 in samples was analysed by flow cytometricbead-based assay. The mean follow-up period was 11 months (range 0-23) from the time of surgery.Results. Serum sVCAM-1 concentrations are positively correlated to ascites sVCAM-1 concentrations. There was aweakly positive correlation of serum sVCAM-1 with tumour size and no correlation with inflammatory tumour markers,FIGO stage or grade. Higher concentrations of sVCAM-1 were associated with poor disease outcome (death fromovarian cancer) in almost all cases before chemotherapy was started.Conclusion. This is the first study demonstrating that serum concentrations of sVCAM-1 in advanced ovarian cancerpatients correlate with sVCAM-1 concentrations in ascites, thus expressing the biologic potential of malignant diseaseto metastasis, rather than systemic inflammation. Higher serum and ascites sVCAM-1 concentrations might have predictivepotential for different biologic behaviour.Source: Radiology and oncology. - ISSN 1318-2099 (Vol. 48, iss. 3, Sep. 2014, str. 307-313, VI)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 30924505
Author
Jakimovska, Marina |
Černe, Katarina |
Verdenik, Ivan |
Kobal, Borut
Topics
ginekologija |
tumorji |
sVCAM-1
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Jakimovska, Marina | 32429 |
Černe, Katarina | 10990 |
Verdenik, Ivan | 05015 |
Kobal, Borut | 06970 |
Source: Personal bibliographies
and: SICRIS
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