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Are there geographical differences in the frequency of SYT-SSX1 and SYT-SSX2 chimeric transcripts in synovial sarcoma?
Koković, Ira ...
Synovial sarcoma (SS) is characterized by the t(Xč18)(p11.2čq11.2) chromosomaltranslocation, which results in generating either SYT-SSX1, SYT-SSX2 or, infrequently, SYT-SSX4 fusion gene. The ratio of ...SYT-SSX1ČSYT-SSX2 fusions is close to 2Č1 in the majority of studies, and SYT-SSX2 fusion has been only rarely observed in biphasic SS. In the present study, we compared two series of patients with SS, Slovenian (37 cases) and Dutch (14 cases), with respect to clinical, pathological and molecular findings. The two groups did not differ with regard to clinicopathological features. Whereas the frequency of different SYT-SSX fusions in the Dutch group was similar to that reported in the literature, we found an unexpectedlyhigh number of tumors with SYT-SSX2 fusion in the Slovenian group.The ratio of SYT-SSX1ČSYT-SSX2 fusion was 7Č18 for monophasic and 2Č7 for biphasic tumors in the Slovenian group. This distribution differs significantly from that observed in the Dutch group in the present study (P = 0.041) as well as from data reported in the recent large multi-institutional study on 243 patients (P = 0.0001). Our findings indicate possible geographical differences in the frequency of two SYT-SSX fusion transcripts inpatients with synovial sarcoma.
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