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  • Antifungal activity of cinnamic acid derivatives involves inhibition of benzoate 4-hydroxylase (CYP53)
    Korošec, Branka ...
    Aims:CYP53A15, from the sorghum pathogen Cochliobolus lunatus is involved in detoxification of benzoate, a key intermediate in aromatic compound metabolism in fungi. Because this enzyme is unique to ... fungi, it is a promising drug target in fungal pathogens of other eukaryotes.Methods and results:In our work we showed high antifungal activity of seven cinnamic acid derivatives against C. lunatus, and two other fungi, Aspergillus niger and Pleurotus ostreatus. In order to elucidate the mechanism of action of cinnamic acid derivatives with the most potent antifungal properties, we studied the interactions between these compounds and the active site of C. lunatus cytochrome P450, CYP53A15. Conclusion:We demonstrated that cinnamic acid and at least four of the 42 tested derivatives inhibit CYP53A15 enzymatic activity.Significance and impact of study:By identifying selected derivatives of cinnamic acid as possible antifungal drugs, and CYP53 family enzymes as their targets, we revealed a potential inhibitor-target system for antifungal drug development. This article is protected by copyright. All rights reserved.
    Source: Journal of applied microbiology. - ISSN 1364-5072 (iss. 4, Vol. 116, Apr. 2014, str. 955-966)
    Type of material - article, component part ; adult, serious
    Publish date - 2014
    Language - english
    COBISS.SI-ID - 31019737
    DOI

source: Journal of applied microbiology. - ISSN 1364-5072 (iss. 4, Vol. 116, Apr. 2014, str. 955-966)
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