ALL libraries (COBIB.SI union bibliographic/catalogue database)
-
Positive feedback between PGE2 and COX2 redirects the differentiation of human dendritic cells towards stable myeloid-derived suppressor cellsObermajer, Nataša ...Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system. We report that the establishment of positive feedback loop between prostaglandin E2 (PGE2) ... and COX2, the key regulator of PGE2 synthesis, represents the determining factor in redirecting the development of CD1a+ DCs to CD14+CD33+CD34+ monocytic MDSCs. Exogenous PGE2 and such diverse COX2 activators as LPS, IL-1? or IFN?, all induce monocyte expression of COX2, blocking their differentiation into CD1a+ DCs andinduce endogenous PGE2, IDO1, IL4R?, NOS2 and IL-10, typical MDSC-associated suppressive factors. Addition of PGE2 to GM-CSF/IL-4-supplemented monocyte cultures is sufficient to induce MDSC phenotype and CTL-suppressive function. In accordance with the key role of PGE2 in the physiologic induction of human MDSCs, the frequencies of CD11b+CD33+ MDSCs in ovarian cancer closely correlate with local PGE2 production, while cancer-promoted induction of MDSCs is strictly COX2-dependent. The disruption of COX2-PGE2 feedback using COX2 inhibitors or EP2- and EP4-antagonists suppresses the production of MDSC-associated suppressive factors and the CTL-inhibitory function of fully-developed MDSCs from cancer patients. The central role of COX2-PGE2 feedback in the induction and persistence of MDSCs highlights the potential for its manipulation to enhance or suppress immune responses in cancer, autoimmunity or transplantation.Dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) show opposing roles in the immune system. We report that the establishment of positive feedback loop between prostaglandin E2 (PGE2) and COX2, the key regulator of PGE2 synthesis, represents the determining factor in redirecting the development of CD1a+ DCs to CD14+CD33+CD34+ monocytic MDSCs. Exogenous PGE2 and such diverse COX2 activators as LPS, IL-1? or IFN?, all induce monocyte expression of COX2, blocking their differentiation into CD1a+ DCs and induce endogenous PGE2, IDO1, IL4R?, NOS2 and IL-10, typical MDSC-associated suppressive factors. Addition of PGE2 to GM-CSF/IL-4-supplemented monocyte cultures is sufficient to induce MDSC phenotype and CTL-suppressive function. In accordance with the key role of PGE2 in the physiologic induction of human MDSCs, the frequencies of CD11b+CD33+ MDSCs in ovarian cancer closely correlate with local PGE2 production, while cancer-promoted induction of MDSCs is strictly COX2-dependent. The disruption of COX2-PGE2 feedback using COX2 inhibitors or EP2- and EP4-antagonists suppresses the production of MDSC-associated suppressive factors and the CTL-inhibitory function of fully-developed MDSCs from cancer patients. The central role of COX2-PGE2 feedback in the induction and persistence of MDSCs highlights the potential for its manipulation to enhance or suppress immune responses in cancer, autoimmunity or transplantation.Source: Blood. - ISSN 0006-4971 (Vol. 118, no. 20, 2011, str. 5498-5505)Type of material - article, component partPublish date - 2011Language - englishCOBISS.SI-ID - 3111793
Author
Obermajer, Nataša |
Muthuswamy, Ravikumar |
Lesnock, Jamie |
Edwards, Robert P. |
Kalinski, Pawel
Topics
dendritske celice |
prostaglandin E2 |
rak jajčnikov |
COX2
Shelf entry
Permalink
- URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year | Impact factor | Edition | Category | Classification | ||||
---|---|---|---|---|---|---|---|---|
JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
Select the library membership card:
If the library membership card is not in the list,
add a new one.
DRS, in which the journal is indexed
Database name | Field | Year |
---|
Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
---|---|
Obermajer, Nataša | 25494 |
Muthuswamy, Ravikumar | |
Lesnock, Jamie | |
Edwards, Robert P. | |
Kalinski, Pawel |
Source: Personal bibliographies
and: SICRIS
Select pickup location:
Material pickup by post
Delivery address:
Address is missing from the member's data.
The address retrieval service is currently unavailable, please try again.
By clicking the "OK" button, you will confirm the pickup location selected above and complete the reservation process.
By clicking the "OK" button, you will confirm the above pickup location and delivery address, and complete the reservation process.
By clicking the "OK" button, you will confirm the address selected above and complete the reservation process.
Notification
Automatic login and reservation service currently not available. You can reserve the material on the Biblos portal or try again here later.
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
Pickup location | Material status | Reservation |
---|
Reservation in progress
Please wait a moment.
Reservation was successful.
Reservation failed.
Reservation...
Membership card:
Pickup location: