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Osteoblastogeneza in adipogeneza v kostnem tkivu pri osteoporozi in osteoartritisu = Isteoblastogenesis and adipogenesis in bone tissue in osteoporosis and osteoarthritis
Dragojevič, Jana ; Marc, Janja
Osteoblastogeneza in adipogeneza sta natančno uravnavana procesa, kjer se iz mezenhimskih matičnih celic (MMC) razvijejo bodisi osteoblasti ali pa adipociti. Usmerjanje razvoja MMC uravnavajo ...specifični transkripcijski faktorji preko mnogih dejavnikov in signalih poti. V osteoporozi sta procesa osteoblastogeneze in adipogeneze obratno povezana zaradi usmerjanja razvoja MMC v adipocite na račun zmanjšanega nastajanja osteoblastov. Pri osteoartritisu sta osteoblastogeneza in adipogeneza manj raziskani. Hipoteza oobratni povezanosti osteoblastogeneze in adipogeneze v osteoporozi je splošno sprejeta, vendar pa študije kažejo na bolj zapleten odnos med tema procesoma ter nakazujejo, da sta osteoblastogeneza in adipogeneza lahko uravnavani neodvisno.
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