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Oxidized forms of dietary antioxidants : friends or foes?Poljšak, Borut, 1976- ; Milisav, IrinaMany clinical trials in which individuals received one or more dietary antioxidants failed to demonstrate conclusive effects of antioxidant supplementation. Antioxidant supplements do not seem to ... protect sufficiently against oxidative stress, oxidative damage or to increase lifespan. Some recent studies implied that antioxidant therapy can even increase mortality. In this paper, the idea is presented that antioxidants in their oxidative forms may have more health-beneficial effects than their reduced forms. It seems that it is not the anti-oxidative potential of the antioxidants that has the major role in health-improvement, but rather their involvement in cell signaling processes, regulation of transcription factor activities and other determinants of gene expression. Although oxidized forms of dietary antioxidants may be toxic, their low concentrations might trigger an adaptive stress response (hormesis) and provoke an increased endogenous antioxidant protection and an activation of damage repair processes. Thus, if proved beneficial, the food supplements should contain also low to moderate concentration of specific antioxidants in their oxidized forms.Source: Trends in food science & technology. - ISSN 0924-2244 (Vol. 39, iss. 2, Oct. 2014, str. 156-166)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 31489241
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source: Trends in food science & technology. - ISSN 0924-2244 (Vol. 39, iss. 2, Oct. 2014, str. 156-166)
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Poljšak, Borut, 1976- | 23172 |
Milisav, Irina | 18825 |
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