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The influence of folate pathway polymorphisms on high-dose methotrexaterelated toxicity and survival in children with non-Hodgkin malignant lymphomaErčulj, Nina ...Background. We evaluated the influence of folate pathway polymorphisms on high-dose methotrexate (HD-MTX) related toxicity in paediatric patients with T-cell non-Hodgkin lymphoma (NHL). Patients and ... methods. In total, 30 NHL patients were genotyped for selected folate pathway polymorphisms. Results. Carriers of at least one MTHFR 677T allele had significantly higher MTX area under the time-concentration curve levels at third MTX cycle (P = 0.003). These patients were also at higher odds of leucopoenia (P = 0.006) or thrombocytopenia (P = 0.041) and had higher number of different HD-MTX-related toxicity (P = 0.035) compared to patients with wild-type genotype. Conclusions. Our results suggest an important role of MTHFR 677C>T polymorphism in the development of HD-MTXrelated toxicity in children with NHL.Source: Radiology and oncology. - ISSN 1318-2099 (Vol. 48, no. 3, Sep. 2014, str. 289-292, V)Type of material - article, component partPublish date - 2014Language - englishCOBISS.SI-ID - 31525337
Author
Erčulj, Nina |
Faganel Kotnik, Barbara |
Debeljak, Maruša |
Jazbec, Janez, 1962- |
Dolžan, Vita
Topics
childhood |
non-Hodgkin lymphoma |
polymorphism |
otroštvo |
ne-Hodgkinov limfom |
polimorfizem
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Erčulj, Nina | 30705 |
Faganel Kotnik, Barbara | 35916 |
Debeljak, Maruša | 15657 |
Jazbec, Janez, 1962- | 10972 |
Dolžan, Vita | 11711 |
Source: Personal bibliographies
and: SICRIS
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