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Synthesis and biological evaluation of potential new inhibitors of the bacterial transferase MraY with a ß-ketophosphonate structure
Auberger, Nicolas ...
Stable analogs of bacterial transferase MraY substrate or product with a pyrophosphate surrogate in their structure are described. ?-ketophosphonates were designed as pyrophosphate bioisosteres and ...were investigated as UDP-GlcNAc mimics. The developed strategy allows introduction of structural diversity at a late stage of the synthesis. The biological activity of the synthesized compounds was evaluated on the MraY enzyme.
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