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A microwave-assisted nucleophilic substitution reaction on a quinoline system: the synthesis of amino analogues of nitroxoline : Bogdan Štefane ... [et al.]Štefane, Bogdan ...A reliable protocol for the synthesis of a series of 8-amino analogues of pharmacologically interesting nitroxoline (5-nitro-8-hydroxyquinoline) is described. The unprecedented displacement of the ... cyanomethoxy group of an O-cyanomethylated quinoline derivative by various primary and secondary aminesselectively affords 5-nitroquinolin-8-ylamines in moderate-to-high yields. The reactions were accelerated significantly under microwave conditions in comparison with conventional heating.Source: Tetrahedron letters. - ISSN 0040-4039 (Vol. 53, no. 15, 2012, str. 1964-1967)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 3200625
Author
Štefane, Bogdan |
Požgan, Franc, kemik |
Sosič, Izidor |
Gobec, Stanislav, 1970-
Topics
organska kemija |
farmakologija |
sinteza |
sinteze podprte z mikrovalovi |
nukleofilna aromatična substitucija |
kinoloni |
nitroksolini |
cianometoksi skupina |
quinolones |
nitroxoline |
cyanomethoxy group |
nucleophilic aromatic substitution |
microwave-assisted synthesis
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Database name | Field | Year |
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Štefane, Bogdan | 18423 |
Požgan, Franc, kemik | 19405 |
Sosič, Izidor | 30816 |
Gobec, Stanislav, 1970- | 15284 |
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