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Inhibition of metalloproteinase and proteasome activities in colon cancer cells by citrus peel extractAdemosun, Ayokunle O. ...Background: Citrus peels are consumed in the form of infusions, candy or wine, based on their well-documented nutritional and medicinal properties. This study sought to investigate the effect of some ... citrus peels' [grapefruit (Citrus paradisii), orange (Citrus sinensis) and shaddock (Citrus maxima)] extracts on matrix metalloproteinase (MMP) and proteasome activities in primary human colonic tumor (Caco-2) and the metastatic cell lines (LoVo and LoVo/ADR) in a bid to explain the possible mechanism by which the peels could manage/prevent colon cancer. Methods: The inhibition of MMP and proteasome activities in the cells by the peel extracts, as well as the identification of phenolic compounds using high-performance liquid chromatography with diode-array detection (HPLC-DAD), was determined. Results: Orange peel extracts had the strongest inhibition of MMP in Caco-2 and LoVo cells, while shaddock had the least. Shaddock peel extracts also had the least MMP inhibition in LoVo/ADR lysates. Grapefruit had the least proteasome inhibition in Caco-2 and LoVo lysates, while there was no significant (p>0.05) difference in the proteasome inhibition of the peel extracts in LoVo/ADR lysates. The extracts inhibited proteasome activity in extract-treated cells, and HPLC fingerprinting of the extracts revealed the presence of some phenolic compounds such as quercetin, caffeic acid, kaempferol, catechin and naringin. Conclusions: The inhibition of MMP and proteasome activities in colon cancer cell lines suggests the potential use of citrus peels as functional food in the management and/or prevention of colon cancer.Source: Journal of basic & clinical physiology & pharmacology. - ISSN 0792-6855 (Vol. 26, no. 5, Sep. 2015, str. 471-477)Type of material - article, component part ; adult, seriousPublish date - 2015Language - englishCOBISS.SI-ID - 32025049
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source: Journal of basic & clinical physiology & pharmacology. - ISSN 0792-6855 (Vol. 26, no. 5, Sep. 2015, str. 471-477)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Ademosun, Ayokunle O. | ![]() |
Oboh, Ganiyu | ![]() |
Passamonti, Sabina | ![]() |
Tramer, Federica | ![]() |
Žiberna, Lovro | 29416 |
Boligon, Aline Augusti | ![]() |
Athayde, Margareth Linde | ![]() |
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