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Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failureBerezin, Alexander E. ...Background: The objective of this study was to assess the relationship between insulin resistance and apoptotic endothelial-derived microparticles (EMPs) in patients with chronic heart failure (CHF). ... Methods: The study involved 300 CHF patients (186 males) aged 48-62 years with angiographically proven coronary artery disease and/or previously defined myocardial infarction. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). EMPs phenotype was determined by flow cytofluorometry. Results: Depending on HOMA-IR cut-off point (over and <2.77 mmol/L%%U/mL) all patients were divided into two cohorts with (n=171) or without (n=129) IR, respectively. Circulating EMPs were higher in CHF patients with IR than in patients without IR. Interestingly, EMPs were directly related to NYHA functional class of CHF, HOMA-IR, NT-pro-BNP, hs-CRP and BMI. There was a significant association between the level of EMPs and HbA1c, gender (r=0.318, p<0.001 for male), age and smoking. On univariate and multivariate regression analysis we found that the NYHA class of CHF,NT-pro-BNP, hs-CRP, and left ventricular ejection fraction (LVEF) appeared to be independent predictors of increased circulatory apoptotic EMPs. The addition of HOMA-IR to the standard model (NYHA class CHF) improved the relative IDI by 19.9% for increased EMPs. For category-free NRI, 10% of events and 24% of non-events were correctly reclassified by the addition of HOMA-IR to the standard model for increased circulating EMPs. Conclusions: IR may be a contributing factor increasing circulating levels of apoptotic EMPs in non-diabetic CHF patients.Source: Clinical chemistry and laboratory medicine. - ISSN 1434-6621 (Vol. 54, iss. 7, Jul. 2016, str. 1259-1267)Type of material - article, component part ; adult, seriousPublish date - 2016Language - englishCOBISS.SI-ID - 32379865
Author
Berezin, Alexander E. |
Kremzer, Alexander A. |
Cammarota, Giovanni |
Zulli, Anthony |
Petrovič, Danijel, 1963- |
Martell-Claros, Nieves |
Sabo, Jan |
Kruzliak, Peter
Topics
microparticles |
chronic heart failure |
insulin resistance |
mikrodelci |
kronično popuščanje srca |
inzulinska rezistenca
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source: Clinical chemistry and laboratory medicine. - ISSN 1434-6621 (Vol. 54, iss. 7, Jul. 2016, str. 1259-1267)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Berezin, Alexander E. | ![]() |
Kremzer, Alexander A. | ![]() |
Cammarota, Giovanni | ![]() |
Zulli, Anthony | ![]() |
Petrovič, Danijel, 1963- | 11252 |
Martell-Claros, Nieves | ![]() |
Sabo, Jan | ![]() |
Kruzliak, Peter | ![]() |
Source: Personal bibliographies
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