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The EULAR Study Group for Registers and Observational Drug Studies : comparability of the patient case mix in the European biologic disease modifying anti-rheumatic drug registersKearsley-Fleet, Lianne ...Objective. Under the auspices of the European League Against Rheumatism (EULAR), a study group of investigators representing European biologic DMARD (bDMARD) registers was convened. The purpose of ... this initial assessment was to collect and compare a cross section of patient characteristics and collate information on the availability of potential confounders within these registers. Methods. Baseline characteristics of patients starting their first bDMARD in an arbitrary year (2008) for the treatment of RA, including demographic and disease characteristics, bDMARD drug details and co-morbidities, were collected and compared across 14 European bDMARD registers. Results. A total of 5320 patients were included. Half the registers had restricted recruitment to certain bDMARDs during the study year. All registers' collected data on age, gender, disease duration, seropositivity for IgM-RF and 28-joint DAS (DAS28). The mean DAS28 ranged from 4.2 to 6.6 and the mean HAQ from 0.8 to 1.9. Current smoking ranged from 9% to 34%. Nine registers reported co-morbidities with varying prevalence. Conclusion. In addition to demonstrating European-wide collaboration across rheumatology bDMARD registers, this assessment identified differences in prescribing patterns, recruitment strategies and data items collected. These differences need to be considered when applying strategies for combined analysis. The lack of a common data model across Europe calls for further work to harmonize data collection across registers.Source: Rheumatology. - ISSN 1462-0324 (Vol. 54, iss. 6, Jun. 2015, str. 1074-1079)Type of material - article, component partPublish date - 2015Language - englishCOBISS.SI-ID - 32506585
Author
Kearsley-Fleet, Lianne |
Závada, Jakub |
Lund Hetland, Merete |
Nordström, Dan C. |
Aaltonen, Kalle J. |
Listing, Joachim |
Zink, Angela |
Gati, Tamas |
Rojkovich, Bernadette |
Rotar, Žiga
Topics
rheumatoid arthritis |
biologic drugs |
epidemiology |
revmatoidni artritis |
biološka zdravila |
epidemiologija
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Kearsley-Fleet, Lianne | ![]() |
Závada, Jakub | ![]() |
Lund Hetland, Merete | ![]() |
Nordström, Dan C. | ![]() |
Aaltonen, Kalle J. | ![]() |
Listing, Joachim | ![]() |
Zink, Angela | ![]() |
Gati, Tamas | ![]() |
Rojkovich, Bernadette | ![]() |
Rotar, Žiga | 30545 |
Source: Personal bibliographies
and: SICRIS
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