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Karcinoza možganskih ovojnic in rak dojk : 11-letni rezultati zdravljenja z obsevanjem = Leptomeningeal carcinomatosis and breast cancer : 11-year treatment outcomes with radiation therapyŽnidarič, Tanja, zdravnica ; Ratoša, IvicaUvod: Karcinoza možganskih ovojnic (LMK) nastane z zasevanjem tumorskih celic na možganske ovojnice in pomeni slabo prognozo. Obsevanje je ena izmed možnosti zdravljenja za ublažitev nevroloških ... simptomov. Metode: V retrospektivno analizo smo vključili 423 bolnic z rakom dojke (RD) in možganskimi zasevki (MZ) ali LMK, ki so se v obdobju med 2005 in 2015 z obsevanjem glave zdravile na Onkološkem inštitutu Ljubljana. Podrobneje smo analizirali skupino bolnic z LMK, za katere smo tudi preverili uporabnost dveh prognostičnih lestvic preživetja, Breast Graded Prognostic Assessment (Breast-GPA) in Simple Survival Score for Brain Metastases (SS-BM). Rezultati: Z obsevanjem glave smo v opazovanem obdobju zdravili 70 bolnic z LMK. Srednji čas od diagnoze RD do pojava LMK je znašal 4,3 leta, vendar je bil ta čas najkrajši pri trojno negativnem in najdaljši pri luminal A podtipu RD. Srednje celokupno preživetje je za bolnice z MZ in LMK znašalo 7,5 (95-% interval zaupanja, IZ; 6,3%8,8) in 2,3 meseca (95-% IZ; 1,5%3,2) (p < 0,005) ter se je razlikovalo glede na molekularni podtip RD. Na daljše preživetje ni vplivala višja prejeta doza obsevanja (% 20 Gy vs. > 20 Gy). Z analizo smo potrdili prognostično vrednost lestvice Breast-GPA (p < 0,005) in SS-BM (p = 0,044). Zaključki: Pričakovano preživetje se je v naši skupini analiziranih bolnic z LMK razlikovalo glede na stanje zmogljivosti, molekularni podtip RD ter seštevek točk prognostične lestvice.Source: Onkologija : strokovni časopis za zdravnike. - ISSN 1408-1741 (Letn. 23, št. 1, jun. 2019, str. 18-26)Type of material - article, component partPublish date - 2019Language - slovenianCOBISS.SI-ID - 3257979
source: Onkologija : strokovni časopis za zdravnike. - ISSN 1408-1741 (Letn. 23, št. 1, jun. 2019, str. 18-26)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Žnidarič, Tanja, zdravnica | |
Ratoša, Ivica | 34883 |
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