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Dual inhibitor of MurD and MurE ligases from Escherichia coli and Staphylococcus aureusTomašič, Tihomir ...MurD and MurE ligases, consecutive enzymes participating in the intracellular steps of bacterial peptidoglycan biosynthesis, are important targets for antibacterial drug discovery. We have designed, ... synthesized and evaluated the first D-glutamic acid-containing dual inhibitor of MurD and MurE ligases from Escherichia coli and Staphylococcus aureus (IC50s between 6.4 and 180 [micro]M possessing antibacterial activity against Gram-positive S. aureus and its methicillin-resistant strain (MRSA) with minimal inhibitory concentration (MIC) values of 8 [micro]g/mL. The inhibitor was also found to be non-cytotoxic for human HepG2 cells at concentrations below 200 [micro]M.Source: ACS Medicinal Chemistry Letters. - ISSN 1948-5875 (Vol. 3, issue 8, 2012, str. 626-630)Type of material - article, component partPublish date - 2012Language - englishCOBISS.SI-ID - 3274865
Author
Tomašič, Tihomir |
Šink, Roman |
Zidar, Nace |
Fic, Anja |
Contreras-Martel, Carlos |
Dessen, Andréa |
Patin, Delphine |
Blanot, Didier |
Müller-Premru, Manica |
Gobec, Stanislav, 1970- |
Zega, Anamarija |
Kikelj, Danijel |
Peterlin-Mašič, Lucija
Topics
antibacterial agent |
inhibitor |
Mur ligase |
peptidoglycan |
2-thioxothiazolidin-4-one
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Tomašič, Tihomir | 28334 |
Šink, Roman | 28862 |
Zidar, Nace | 28905 |
Fic, Anja | 33295 |
Contreras-Martel, Carlos | |
Dessen, Andréa | |
Patin, Delphine | |
Blanot, Didier | |
Müller-Premru, Manica | 12193 |
Gobec, Stanislav, 1970- | 15284 |
Zega, Anamarija | 18633 |
Kikelj, Danijel | 01463 |
Peterlin-Mašič, Lucija | 19317 |
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