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Excretion profile of glycyrrhizin metabolite in human urine
Kočevar Glavač, Nina ; Kreft, Samo
Glycyrrhizin is the main pharmacologically active component in licorice. Long term consumption of higher amounts of glycyrrhizin results in serious side effects (pseudoaldosteronism) caused by the ...glycyrrhizin metabolite 3b-monoglucuronyl-18b-glycyrrhetinic acid (3-MGA). The aim of this study was to determine urine excretion profile of 3-MGA. Six healthy volunteers ingested 600 mg of glycyrrhizin. In the first experimental period, glycyrrhizin was ingested in the morning and in the second experimental period, which followed after 2 weeks, glycyrrhizin was ingested in the evening. Results showed that the amount of excreted 18-MGA in urine was 1425.9-3147.8 lg, which corresponds to 0.31-0.67% of the ingested dose. Maximum elimination rates were 31.52-209.47 lg/h. There were no significant differences in the amount of excreted 3-MGA as well as in elimination rates of3-MGA when glycyrrhizin was ingested in the morning or evening, respectively. These results provide some important clinical data on glycyrrhizin metabolism.
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