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Three types of functional regulatory T cells control T cell responses at the human maternal-fetal interface [Elektronski vir]Salvany-Celades, Maria ...During pregnancy, maternal regulatory T cells (Tregs) are important in establishing immune tolerance to invading fetal extravillous trophoblasts (EVTs). CD25HIFOXP3+ Tregs are found at high levels in ... decidual tissues and have been shown to suppress fetus-specific and nonspecific responses. However, limited data are available on additional decidual Treg types and the mechanisms by which they are induced. This study investigated three distinct decidual CD4+ Treg types in healthy pregnancies with a regulatory phenotype and the ability to suppress T cell responses: CD25HIFOXP3+, PD1HIIL-10+, and TIGIT+FOXP3dim. Moreover, co-culture of HLA-G+ EVTs or decidual macrophages with blood CD4+ T cells directly increased the proportions of CD25HIFOXP3+ Tregs compared to T cells cultured alone. EVTs also increased PD1HI Tregs that could be inhibited by HLA-C and CD3 antibodies, suggesting an antigen-specific induction. The presence of distinct Treg types may allow for the modulation of a variety of inflammatory responses in the placenta.Source: Cell reports [Elektronski vir]. - ISSN 2211-1247 (Vol. 27, iss. 9, May 2019, str. 2537-2547)Type of material - e-articlePublish date - 2019Language - englishCOBISS.SI-ID - 3320955
Author
Salvany-Celades, Maria |
Zwan, Anita van der |
Benner, Marilen |
Šetrajčič Dragoš, Vita |
Bougleux Gomes, Hannah Ananda |
Iyer, Vidya |
Norwitz, Errol R. |
Strominger, Jack L. |
Tilburgs, Tamara
Topics
T celice |
imunska toleranca |
nosečnost |
molekularna diagnostika |
T cells |
immune tolerance |
pregnancy |
molecular diagnostics
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Salvany-Celades, Maria | ![]() |
Zwan, Anita van der | ![]() |
Benner, Marilen | ![]() |
Šetrajčič Dragoš, Vita | 51870 |
Bougleux Gomes, Hannah Ananda | ![]() |
Iyer, Vidya | ![]() |
Norwitz, Errol R. | ![]() |
Strominger, Jack L. | ![]() |
Tilburgs, Tamara | ![]() |
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