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Small cell and large cell neuroendocrine carcinoma of the larynx : a comparative analysisStrojan, Primož ...The poorly differentiated neuroendocrine carcinomas (NECs) of the larynx are rare tumors that comprise of a small cell-type (SCNEC) and a large cell-type (LCNEC). In order to consolidate the current ... knowledge about their characteristics and management a systematic review of the available literature was performed. The PubMed/Medline and Scopus databases search resulted in 141 articles published between 1972 and 2019, describing 273 patients: 230 cases were of SCNEC histology (84.2%) and 43 cases were LCNECs (15.8%). Comparing both histological entities, patients with LCNECs were older (63.2 vs. 58.7%years, p = 0.036) than SCNEC patients and had more often primary tumor in a supraglottic larynx (79.5 vs. 56.1%, p = 0.039), advanced-stage neck disease (N2-3, 56.8 vs. 40%, p = 0.061), surgery-based treatment (83.7 vs. 51.9%, p < 0.001) and had no radiotherapy (44.2 vs. 29%, p = 0.071). At presentation, systemic metastases were diagnosed in 12.1% of the patients, whereas disease relapse was experienced by two-thirds (65.3%) of those initially staged M0; systemic relapse, alone or in combination with local/regional recurrence, was the most frequent type of failure (in 71.9%). On multivariate analysis, more advanced disease stage and SCNEC histology adversely influenced disease-specific survival. Wide variations in the pattern of care, including radiotherapy doses and chemotherapy regimens, were found among long-term survivors without known disease at >24%months of follow-up (N = 36). We conclude that the most effective treatment for poorly differentiated NECs has yet to be determined.Source: Cancer treatment reviews. - ISSN 0305-7372 (Vol. 78, 2019, str. 42-51)Type of material - article, component partPublish date - 2019Language - englishCOBISS.SI-ID - 3328123
Author
Strojan, Primož |
Hernandez-Prera, Juan C. |
Beitler, Jonathan J. |
Eisbruch, Avraham |
Saba, Nabil F. |
Mendenhall, William M. |
Suárez, Carlos, zdravnik |
Smee, Robert |
Rinaldo, Alessandra |
Ferlito, Alfio
Topics
nevroendokrini tumorji |
grlo |
zdravljenje |
neuroendocrine tumors |
larynx |
therapy
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Strojan, Primož | 14576 |
Hernandez-Prera, Juan C. | ![]() |
Beitler, Jonathan J. | ![]() |
Eisbruch, Avraham | ![]() |
Saba, Nabil F. | ![]() |
Mendenhall, William M. | ![]() |
Suárez, Carlos, zdravnik | ![]() |
Smee, Robert | ![]() |
Rinaldo, Alessandra | ![]() |
Ferlito, Alfio | ![]() |
Source: Personal bibliographies
and: SICRIS
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