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Rak jajčnikov = Ovarian cancerAnzeljc, Veronika ; Takač, Iztok ; Arko, DarjaRak jajčnikov v zgodnjih stadijih navadno ne povzroča bolezenskih znakov, na osnovi katerih bi lahko posumili nanj. Pri obravnavi bolnic je potrebna natančna anamneza, klinični pregled celega telesa ... ter ginekološki in rektalni pregled. Pred operativnim posegom rentgensko slikamo pljuča, naredimo ginekološki ultrazvok (UZ) in CT preiskavo trebuha ter medenice. Potrebne so laboratorijske preiskave ter določitev tumorskih označevalcev CA 125 in karcinoembrionalnega antigena (CEA). Najpomembnejši del zgodnjega zdravljenja je natančna staging laparotomija. Dopolnilno zdravljenje s citostatiki je potrebno pri vseh bolnicah razen pri dobro diferenciranih tumorjih v stadijih IA in I8. Prva izbira sistemskega zdravljenja pri epitelnih ovarijskih tumorjih je kombinacija derivatov platine (cisplatin ali pogosteje karboplatin) v kombinaciji s paklitakselom. Najpomembnejši napovedni dejavnik poteka bolezni je prostornina preostale bolezni. V nekaterih primerih je potrebna sekundama citoredukcija, pri kateri odstranimo rakasto tkivo kadarkoli po končanem sistemskem zdravljenju. Ponovitve bolezni po več kot šestih mesecih zdravimo z derivati platine, po več kot enem letu pa v kombinaciji s paklitakselom. Kadar se bolezen ponovi prej kot v šestih mesecih, zdravimo z liposomalnim doksorubicinom, topotekanom, etopozidom ali gemcitabinom. V primeru, da se bolezen ponovi samo na enem mestu, je zdravljenje lahko tudi kirurško.Source: Medicinski mesečnik. - ISSN 1854-1313 (Letn. 4, št. 10/12, okt.-dec. 2008, str. 231-236)Type of material - article, component part ; adult, seriousPublish date - 2008Language - slovenianCOBISS.SI-ID - 3330367
Author
Anzeljc, Veronika |
Takač, Iztok |
Arko, Darja
Topics
Ovarian Neoplasms |
epidemiology |
diagnosis |
therapy |
surgery |
Jajčnik, novotvorbe |
Epidemiologija |
Diagnostika |
Zdravljenje |
Kirurgija |
Chemotherapy, Adjuvant |
Kemoterapija, pomožna
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JCR | SNIP | JCR | SNIP | JCR | SNIP | JCR | SNIP |
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Anzeljc, Veronika | 38000 |
Takač, Iztok | 01324 |
Arko, Darja | 14114 |
Source: Personal bibliographies
and: SICRIS
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