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  • Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis
    Ilić, Miloš ...
    Esters of 1,4-benzoxazine and 1,4-benzodioxine compounds 1 and 10, which combine thrombin inhibitory and GPIIb/IIIa antagonistic activity in one molecule are shown to inhibit endothelial cell ... migration and tube formation in vitro and angiogenesis in the chicken chorioallantoic membrane (CAM) assay. The corresponding carboxylic acids 1 (R2 = H) and 11 were devoid of antiangiogenic activity, most probably due to their insufficient entry into the cell. Although thrombin inhibition remains the most probable explanation for their inhibition of angiogenesis, VEGFR2 kinase assay suggest that other targets such as VEGFR2 might be involved.
    Source: European journal of medicinal chemistry. - ISSN 0223-5234 (Vol. 58, December 2012, str. 160-170)
    Type of material - article, component part
    Publish date - 2012
    Language - english
    COBISS.SI-ID - 3331441

    Link(s):

    http://www.sciencedirect.com/science/article/pii/S0223523412006046?v=s5#
    DOI

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