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The level of heparin-induced antibodies in correlation with the result of the flow cytometric functional assay in the patients with suspected HITMaličev, Elvira ...Heparin can induce the formation of antibodies against a heparin complex with a platelet factor 4 (PF4), leading to platelet activation and the development of heparin-induced thrombocytopaenia (HIT). ... Because screening ELISA does not discriminate between platelet activating and non-activating anti-heparin/PF4 antibodies, each positive result is confirmed by an additional functional assay. We analysed 1004 sera of patients with suspected HIT. Optical density (OD) values of ELISA-positive results were correlated with the risk for a positive result with our functional flow cytometric assay. Only 10.7% were ELISA positive and 59.8% of those were positive with the functional assay. The positive functional assay was found in 23.4% of patients with OD<1.0, in 57.7% with 1.0<OD<2.0 and in 94.1% with OD>2.0. Although our results showed that higher ELISA OD values increasethe possibility of the presence of platelet-activating anti-heparin/PF4 antibodies - , there is no need for improving ELISA cut-off value for positive result.Source: Journal of clinical pathology. - ISSN 0021-9746 (Vol. 70, iss. 12, Dec. 2017, str. 1084-1087)Type of material - article, component partPublish date - 2017Language - englishCOBISS.SI-ID - 33396185
Author
Maličev, Elvira |
Maček, Marjeta, 1966- |
Klemenc, Polona |
Rožman, Primož, 1954-
Topics
heparin |
protitelesa |
trombocitopenija |
heparin |
antibodies |
thrombocytopaenia
source: Journal of clinical pathology. - ISSN 0021-9746 (Vol. 70, iss. 12, Dec. 2017, str. 1084-1087)
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Maličev, Elvira | 21228 |
Maček, Marjeta, 1966- | 20610 |
Klemenc, Polona | 21525 |
Rožman, Primož, 1954- | 12336 |
Source: Personal bibliographies
and: SICRIS
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