ALL libraries (COBIB.SI union bibliographic/catalogue database)
13.
DPP4 inhibitor sitagliptin as a potential treatment option in metformin intolerant obese women with polycystic ovary syndrome : a pilot randomized study
Objective: Metformin has an established role in the management of polycystic ovary syndrome (PCOS). Some patients cannot tolerate it due to associated gastrointestinal adverse events. The present ...study evaluated DPP4 inhibitor sitagliptin as a potential treatment option in metformin intolerant PCOS. Design: We conducted a 12-week prospective randomized open-label study with 30 obese metformin intolerant women with PCOS (aged 35.0+-7.2 years, BMI 36.9+-5.5 kg/m2). After metformin withdrawal they were randomized to lifestyle intervention and sitagliptin 100mg QD (SITA) or lifestyle intervention alone as controls (CON). Methods: All participants underwent anthropometric and endocrine measurements and OGTT. Model derived indexes of insulin resistance (IR) and beta-cell function were calculated. Results: SITA improved beta-cell function as assessed by homeostasis model assessment for beta-cell function index (HOMA-B) for 45.9+-35.8 (p=0.001), modified beta-cell function index (MBCI) for 7.9+-7 (p=0.002) and quantitative insulin sensitivity check index (QUICKI) for -0.03+-0.03 (p=0.002). By contrast, beta-cell function decreased in CON. The between group differences were significant for HOMA-B (p=0.000), MBCI (p=0.010) and QUICKI (p=0.025). The conversion rate to impaired glucose homeostasis was prevented in SITA: 3/15 of subjects had IGT before and after the study. In CON none had T2D and 4 had IGT at the beginning. After 12 weeks IGT was observed in 2 and T2D in 3 subjects. Conclusion: SITA improved beta-cell function and prevented a conversion rate to IGT and T2D in metformin intolerant obese PCOS.
It was not necessary to add the material to the shelf.
Bibliographic material was successfully added on shelf.
Adding bibliographical material on shelf was not successful.
Material is already on the shelf.
Permalink
URL:
Impact factor
Access to the JCR database is permitted only to users from Slovenia. Your current IP address is not on the list of IP addresses with access permission, and authentication with the relevant AAI accout is required.
Year
Impact factor
Edition
Category
Classification
JCR
SNIP
JCR
SNIP
JCR
SNIP
JCR
SNIP
Select the library membership card:
DRS,
in which the journal is indexed
Database name
Field
Year
Links to authors' personal bibliographies
Links to information on researchers in the SICRIS system
Subject headings in COBISS General List of Subject Headings
Select pickup location
The material from the parent unit is free. If the material is delivered to the pickup location from another unit, the library may charge you for this service.
