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A novel beads-based dissolution method for the in vitro evaluation of extended release HPMC matrix tablets and the correlation with the in vivo dataKlančar, Uroš ...The aim of this work was to establish alternative in vitro dissolution method with good discrimination and in vivo predictability for the evaluation of HPMC extended release matrix tablets. For this ... purpose, two different HPMC matrix tablet formulations were first evaluated by a range of conventional dissolution testing methods using apparatus 1, apparatus 2, and apparatus 3 according to US Pharmacopoeia. Obtained results showed low discrimination between the tested samples. Afterward, a novel dissolution testing method which combines plastic beads and apparatus 3 was developed with the aim to better mimic the mechanical forces that occur in vivo. Results showed that sufficiently large mechanical stress with high dips per minute program setting(apparatus 3) was needed to obtain in vitro discriminative results, which are in accordance with the in vivo data. The in vivo relevance of the method was confirmed with the establishment of the level A in vitro-in vivo correlation.Source: The AAPS Journal [Elektronski vir]. - ISSN 1550-7416 (Vol. 15, no. 1, 2013, str. 267-277)Type of material - article, component partPublish date - 2013Language - englishCOBISS.SI-ID - 3359601
Author
Klančar, Uroš |
Markun, Boštjan |
Baumgartner, Saša, 1969-2015 |
Legen, Igor
Topics
dissolution method |
extended release |
HPMC |
IVIVC |
matrix tablets |
quality by design
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Database name | Field | Year |
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Links to authors' personal bibliographies | Links to information on researchers in the SICRIS system |
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Klančar, Uroš | 33368 |
Markun, Boštjan | 23397 |
Baumgartner, Saša, 1969-2015 | 15104 |
Legen, Igor | 20369 |
Source: Personal bibliographies
and: SICRIS
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